বিস্তারিত

Generic:

• Generic Name: Acitretin

Indications:

• Primary Use: Treatment of severe psoriasis and other severe skin conditions that are not responsive to conventional treatments.

Pharmacology:

• Mechanism of Action: Acitretin is a retinoid that modifies the growth and differentiation of epithelial cells. It works by normalizing skin cell production and reducing inflammation.

Dosage & Administration:

• Adult Dose: Typically, the starting dose is 10-30 mg once daily, adjusted based on response and tolerability. The usual dose ranges from 10 to 50 mg per day.
• Administration: Should be taken with food to improve absorption.

Interaction:

• Drug Interactions: Can interact with other medications such as methotrexate, tetracyclines, and alcohol. May increase the risk of adverse effects if used with certain drugs.
• Food Interactions: Avoid alcohol, as it can exacerbate the drug’s side effects.

Contraindications:

• Pregnancy: Contraindicated in pregnancy due to the risk of severe birth defects. Women of childbearing potential must use effective contraception.
• Hypersensitivity: Contraindicated in patients with known hypersensitivity to acitretin or any of its components.

Side Effects:

• Common Side Effects: Dry skin, chapped lips, dry eyes, and nosebleeds.
• Serious Side Effects: Liver toxicity, elevated cholesterol levels, and potential for severe skin reactions. Regular monitoring is necessary.

Pregnancy & Lactation:

• Pregnancy: Acitretin is highly contraindicated in pregnancy due to its teratogenic effects. Women must avoid pregnancy during treatment and for at least 3 years after discontinuation.
• Lactation: It is not recommended during breastfeeding due to potential risks to the infant.

Precautions & Warnings:

• Regular Monitoring: Periodic liver function tests and lipid profiles are required.
• Photosensitivity: Patients should avoid prolonged sun exposure and use sun protection.

Use in Special Populations:

• Pediatric Use: Safety and efficacy in children have not been established.
• Geriatric Use: Use with caution in elderly patients, who may be more sensitive to the drug’s effects.

Therapeutic Class:

• Class: Retinoid

Storage Conditions:

• Storage: Store at room temperature, away from moisture and heat. Keep out of reach of children.

Always consult a healthcare professional for personalized advice and information.