বিস্তারিত

Adryl (Diphenhydramine Hydrochloride) Syrup

Indications: Adryl is indicated for the treatment of the following conditions:

• Seasonal, perennial, and vasomotor rhinitis
• Urticaria, angioneurotic edema, and anaphylaxis
• Pruritic conditions
• Premedication for emesis and motion sickness
• Miscellaneous conditions such as Meniere’s disease and parkinsonism

Pharmacology: Diphenhydramine, the active ingredient in Adryl, is an antihistamine with anticholinergic and sedative properties. It competes with histamine for H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract, thereby alleviating allergic symptoms.

Dosage Guidelines:

For Adults:

• Allergic conditions: 25-50 mg, three times daily, with an additional 50 mg at bedtime if needed.

For Children:

• Ages 1-5: 5 mg (2.5 ml of syrup) four times daily.
• Ages 6 and above: 10 mg (5 ml of syrup) four times daily.

Route of Administration:

• Administered orally.

Interactions:

• Adryl reduces the absorption of para-aminosalicylic acid (PAS), an antituberculous agent, from the gastrointestinal tract.
• CNS depressants can enhance the sedative effects of Adryl.
• Anticholinergic drugs may amplify Adryl’s anticholinergic side effects.

Contraindications:

• Hypersensitivity to Diphenhydramine Hydrochloride.
• Ammonium chloride is contraindicated in patients with impaired hepatic or renal function.

Side Effects: Possible side effects include:

• Sedation, dizziness, tinnitus, fatigue, ataxia, blurred vision, diplopia, euphoria, and gastrointestinal discomfort.

Pregnancy & Lactation:

• Category B: There are no adequate and well-controlled studies in pregnant women. Diphenhydramine should only be used during pregnancy if clearly necessary.
• Diphenhydramine is excreted in breast milk, and its use in breastfeeding mothers is not recommended.

Precautions & Warnings:

• Exercise caution in patients where drowsiness could impair functioning, such as drivers or machine operators.
• Alcohol and CNS depressants may intensify drowsiness.

Therapeutic Class:

• Sedating antihistamine.

Storage Conditions:

• Store at temperatures between 15-30°C and protect from moisture.

Manufactured by:

• Square Pharmaceuticals Ltd.