বিস্তারিত

Indications: Acitrin (Cetirizine) is indicated for the relief of symptoms associated with allergic rhinitis (seasonal or perennial) and chronic urticaria (hives).

Pharmacology: Cetirizine, the active ingredient in Acitrin, is a second-generation antihistamine. It works by selectively inhibiting peripheral H1 receptors, preventing histamine from causing allergy symptoms like itching, swelling, and redness.

Dosage & Administration:

• Adults and children over 12 years: 1 tablet (10 mg) once daily.
• Children aged 6-12 years: 5 mg (half tablet) twice daily.
• Dosage adjustments may be needed for renal impairment.

Interaction:

• May interact with sedatives, alcohol, and other central nervous system depressants, enhancing drowsiness.
• Avoid use with theophylline and ritonavir as it may increase the concentration of Cetirizine.

Contraindications:

• Hypersensitivity to Cetirizine or any of its components.
• Severe renal impairment (Creatinine clearance < 10 mL/min).

Side Effects: Common side effects include drowsiness, dry mouth, dizziness, and fatigue. Rarely, it may cause an allergic reaction, including difficulty breathing or swelling.

Pregnancy & Lactation:

• Pregnancy: Cetirizine should be used with caution during pregnancy, especially in the first trimester.
• Lactation: Cetirizine can pass into breast milk, so it should be used cautiously during breastfeeding.

Precautions & Warnings:

• Use caution in patients with renal or hepatic impairment.
• Avoid operating heavy machinery or driving if drowsiness occurs.

Use in Special Populations:

• Elderly: Use with caution as renal function may be reduced.
• Children: Safe for children above 6 years, dosage adjustment is required.

Therapeutic Class: Anti-histamine, non-sedative type.

Storage Conditions: Store below 30°C in a cool, dry place, away from direct light. Keep out of reach of children.